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KMID : 0358319960370010019
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Korean Journal of Urology
1996 Volume.37 No. 1 p.19 ~ p.27
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Combination Therapy with Bacillus Calmette-Guerin(BCG) and Interferon-alpha in Superficial Bladder Cancer Patients: Immune Effector Cell Function and Toxicity
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Abstract
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The aim of this study was to evaluate immune effector cell function and toxicity of adjuvant intravesical bacillus Calmette-Guerin(BCG) plus systemic interferone-αadministration in 12 superficial bladder cancer patients received transurethral
resection. 80mg Pasteur strain BCG was instilled into the bladder at 2 weeks after transurethral resection and carried out once a week for 6 weeks. 3 million units interferon-α 2b was injected subcutaneously at 2 weeks after transurethral
resection and
carried out 3 times a week during the period of BCG therapy.
Natural killer cell activity, Helper T cell/Suppressor T cell (CD4/CD8) ratio and phagocytic activity were devaluated by flowcytometry and toxicity was graded according to WHO guidelines.
@ES The results were as follows:
@EN 1. Natural killer cell activity of interferon-αor BCG in combination with interferone-αtreated group was sitgnificantly increased compared to control or BCG treated group, also the activity of those two groups was significantly correlated
between
pre and post treatment state.
2. CD4/CD8 ratio of interferon-αor BCG treated group, also the activities of those two grous were significanlty correlated between pre and post treatment state.
3. No significant differences in phagocytic activity were between all experimental groups or pre and post treatment state.
4. the toxicity of BCG in combination with interferon-α treated group showed minor to moderate and self-limiting in majority of the patients.
By the results of this study, it is supposed that intravesical BCG instillation in combiation-αinjection increase systemic immune response without significant toxicity and may be effective in prophylaxis of tumor recurrence in the patients with
superficial bladder cancesr.
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KEYWORD
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